Lee Woo-Jin, Andrew (Jo Hyun-Jae)
Lee Woo-Jin, also known as Andrew, is an optimistic, kind-hearted youth who was an orphan mistreated by his aunt. His uncle, Father Peter, who had just returned from Italy, then adopted him. Since then, Andrew was determined to become a priest to help the poor and needy. His belief, however, begins to shift as he encounters Eun-Ha. Attending the same high school and medical school, Andrew and Eun-Ha struggle in their lives against religion and illnesses to keep their love alive.

Cho Eun-Ha (Soo Aeh)
Genuine and strong-minded, Cho Eun-Ha lost her parents and moved into Angel' Place where she met Andrew. Despite Andrew' warm welcome, Eun-Ha remains aloof from him until she learns that he lost his parents as she did. Eun-Ha and Andrew become friends and slowly Eun-Ha begins to fall for Andrew. But as she does so, Andrew reveals his wish to become a priest leaving Eun-Ha to keep her feelings to herself.

Jung Woo-Jin (Ji Jin-Hee)
JJung Woo-Jin is a bright, passionate child from a well-off family. Both his parents are doctors. He, nevertheless, suffers from the fact that Dr. Yim Kyung-Eun who raises him is not his real mother. As Woo-Jin enters Medical School, he runs into Andrew and Eun-Ha, and soon they all become friends. However, his friendship with Andrew ends as he falls for Eun-Ha and learns that Andrew is Yim Kyung-Eun' son.