First, there is the hospital's most fumbling but endearing nurse, Izumi Asakura (Alisa Mizuki), whose thoughts are occupied with the upcoming annual singing contest between hospital wards. First prize is an all-expenses-paid trip to a South Sea island and Izumi is dead set on winning it. Decked out in lavish costume and practicing her dance routine, Izumi dreams of finally taking that honeymoon she and her husband, rookie surgeon Kentaro Takasugi (Naohito Fujiki), never had. But Kentaro's got other things on his mind. He's looking to win the respect and recognition of his colleagues as a promising surgeon. His reaction, "Look, I simply don't have time to go on any honeymoon," doesn't sit well with his pleading wife. A livid Izumi screams: "This marriage was all a mistake. I want a divorce!"

Problems lurk behind every corner at Wakabakai General Hospital. This time, they rain down on head nurse, Shoko Ozaki (Yuki Matsushita). Battling loneliness as her husband, chief surgeon Dr. Sawada, travels across America with his beloved daughter Maria, she soon finds herself at odds with the newly-appointed Chief Nurse, Toshiko Yaguchi (Toshie Negishi). Not one to mince words, Yaguchi bluntly condemns Shoko's way of doing things: "Now that I'm in charge, a lot of things are going to change around here." Shoko's woes compounded, she turns to her biggest ally for help, Chief Executive Nurse Nemoto (Kazuko Yoshiyuki).

Meanwhile, Dr. Yuichi Hamano (Yoshizumi Ishihara) and his wife, nurse Saeko Oshima (Kazue Ito), are awaiting the birth of their second child, and just can't seem to concentrate on much else. The same can be said for the scheming nurse Madoka Akagi (Uno Kanda), who has fallen for a handsome and gentle-natured patient, Soichiro Okita (Ryuji Harada), and spends all her time tending to him. But Soichiro's a bit too nervous about his upcoming organ transplant to pay her much attention.

At Wakabakai General Hospital, normalcy is a rare commodity. But no one could have anticipated the magnitude of the crisis that would soon befall them.

The nurse station is hijacked! And "Leave it to the Nurses" must face its biggest challenge ever!

Tsuyoshi Saruwatari is a former patient who has just been released from the hospital. No sooner is he out, however, when he begins longing for those blissful days under the tender loving care of head nurse, Shoko Ozaki. He tries desperately to get himself readmitted. But his hopes are dashed when Chief Nurse Yaguchi finally has him ejected from the building. Determined to get his way, he resorts to brandishing a machine gun and storming the place. When word gets out that a madman has occupied the nurse's station, the police and media converge on Wakabakai General Hospital. Detective Kumano (Keizo Kanie) arrives to take command of the police response effort but fails to get Saruwatari's to abandon his stubborn demand to be readmitted. With the situation beginning to spin out of control, it's only a matter of time that something goes terribly amiss?

How will Izumi and her fellow nurses overcome through this crisis?